Brochure Information for Ofloxacin 200 mg Injection

Brand Name:
Ofolopars

Generic Name:
Ofloxacin – a broad-spectrum antibiotic from the fluoroquinolone family that inhibits the enzyme DNA gyrase, thereby preventing bacterial growth and replication.

Dosage Form:
Intravenous injection solution. Each vial contains 200 mg of Ofloxacin in an appropriate volume for slow intravenous administration.

Drug Classification:
Antibiotic – Fluoroquinolone group

Indications (Uses)

• Treatment of acute and chronic respiratory tract infections (such as bronchitis, pneumonia, and sinusitis)
• Treatment of urinary tract infections (including pyelonephritis, cystitis, and recurrent infections)
• Treatment of skin and soft tissue infections such as cellulitis
• Treatment of gastrointestinal infections caused by susceptible bacteria
• May be used for certain sexually transmitted infections (under the supervision of a physician)

Dosage and Administration

• Adults: The usual dose is 200 mg every 12 hours, administered as a slow intravenous infusion over at least 30 minutes.
• Duration of treatment depends on the type and severity of infection (typically 5–10 days).
• In patients with renal impairment, dosage should be adjusted according to creatinine clearance.

Contraindications

• Hypersensitivity to Ofloxacin or other quinolone antibiotics
• Pregnancy and breastfeeding (due to placental and breast milk transfer)
• Children and adolescents under 18 years (because of possible effects on cartilage and bone development)

Warnings and Precautions

• Risk of tendon rupture, especially in elderly patients or those using corticosteroids
• Avoid driving or operating machinery if dizziness or drowsiness occurs
• Avoid exposure to sunlight or UV lamps due to photosensitivity
• Use with caution in patients with a history of seizures or central nervous system disorders

Common Side Effects

• Gastrointestinal: nausea, vomiting, diarrhea, abdominal pain
• Neurological: dizziness, insomnia, anxiety, headache
• Allergic reactions: skin rash, itching, urticaria (hives)
• Liver effects: elevated liver enzymes or hepatic dysfunction

Drug Interactions

• Antacids, iron, magnesium, and zinc supplements: reduce absorption of Ofloxacin
• Warfarin: increased risk of bleeding (monitor INR closely)
• Anticonvulsants (e.g., phenytoin, carbamazepine): may increase neurological side effects
• QT-prolonging drugs: increased risk of cardiac arrhythmia

Storage Conditions

• Store at temperatures below 25°C
• Protect from freezing
• Keep away from direct sunlight

Important Notes and Supply Conditions

• For use only by medical personnel
• In case of severe allergic reactions (such as facial swelling or shortness of breath), seek immediate medical attention
• Use the medication strictly as prescribed by your doctor and complete the full treatment course, even if symptoms improve early

Manufacturer Address:
Industrial Town, Phase 3, Sosan 5, Herat
Parsawa Injectable Solutions Manufacturing Company